For a full list of publications see Google Scholar:


W. Poon, Y.N. Zhang, B. Ouyang, B.R. Kingston, J.L.Y. Wu, S. Wilhelm, W.C.W. Chan, "Elimination Pathways of Nanoparticles"
ACS Nano, 2019, 13, 5, 5785-5798. DOI: 10.1021/acsnano.9b01383

DOI: 10.1021/acsnano.9b01383 | PDF (2.9 MB)


N.D. Donahue, H. Acar, S. Wilhelm, "Concepts of Nanoparticle Cellular Uptake, Intracellular Trafficking, and Kinetics in Nanomedicine"
Advanced Drug Delivery Reviews, 2019, accepted. DOI: 10.1016/j.addr.2019.04.008

DOI: 10.1016/j.addr.2019.04.008 | PDF (4.5 MB)


M. Pacal, J. M. Sivak, S. Wilhelm, D. Fonn, "System and Method for Quantifying the Presence of Chemical and/or Physical Conditions in Ocular Tissues"
International Application No. CA/2018/051477

WIPO: WO/2019/095080 | PDF (2 MB)


J. Lazarovits, Y.Y. Chen, F. Song, W. Ngo, A.J. Tavares, Y.N. Zhang, J. Audet, B. Tang, Q. Lin, M.C. Tleugabulova, S. Wilhelm, J.R. Krieger, T. Mallevaey, W.C.W. Chan, “Synthesis of Patient-Specific Nanomaterials'”
Nano Letters, 2018, 19, 116-123

DOI: 10.1021/acs.nanolett.8b03434 | PDF (4.8 MB)


S. Wilhelm, R.C. Bensen, N.R. Kothapalli, A.W.G. Burgett, R. Merrifield, C. Stephan, "Quantification of Gold Nanoparticle Uptake into Cancer Cells using Single Cell ICP-MS"
PerkinElmer Application Note, 2018, 1-4

PDF (1.0 MB)


Q.Dai, S. Wilhelm, D. Ding, A.M. Syed, S. Sindhwani, Y. Zhang, Y.Y. Chen, P. MacMillan, W.C.W. Chan, "Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors"
ACS Nano, 2018, 12, 8423-8435

DOI: 10.1021/acsnano.8b03900 | PDF (7.2 MB)


S. Wilhelm, “Perspectives for upconverting nanoparticles“
ACS Nano, 2017, 11, 10644–10653

DOI: 10.1021/acsnano.7b07120   |   PDF (4.8 MB)


A.M. Syed*, S. Sindhwani*, S. Wilhelm, B.R. Kingston, D.S.W. Lee, J.L. Gommerman, W.C.W. Chan, “Three-dimensional imaging of transparent tissues via metal nanoparticle labeling”
JACS, 2017, 139, 9961-9971

Highlighted on journal cover page (JACS; Volume: 139; Issue: 29; July 26, 2017)
* authors contributed equally

DOI: 10.1021/jacs.7b04022   |   PDF (2.4 MB)


C. Würth, M. Kaiser, S. Wilhelm, B. Grauel, T. Hirsch. U. Resch-Genger, “Excitation power dependent population pathways and absolute quantum yields of upconversion nanoparticles in different solvents”
Nanoscale, 2017, 9, 4283-4294

DOI: 10.1039/C7NR00092H   |   PDF (1.4 MB)


S. Sindhwani*, A.M. Syed*, S. Wilhelm, W.C.W. Chan, “Exploring passive clearing for 3D optical imaging of nanoparticles in intact tissues”
Bioconjugate Chemistry, 2017, 28, 253-259

Highlighted on journal cover page (Bioconjugate Chemistry; Volume: 28; Issue: 1; January 18, 2017)
* authors contributed equally

DOI: 10.1021/acs.bioconjchem.6b00500   |   PDF (2.4 MB)


S. Wilhelm, A.J. Tavares, W.C.W. Chan, “Reply to ‘Evaluation of nanomedicines: stick to the basics'”
Nature Reviews Materials, 2016, 1, 16074

DOI: 10.1038/natrevmats.2016.74   |   PDF (0.2 MB)


M. Del Barrio, R. Cases, V. Cebolla, T. Hirsch, S. De Marcos, S. Wilhelm, J. Galbán, “A reagentless enzymatic fluorescent biosensor for glucose based on upconverting glasses, as excitation source, and chemically modified glucose oxidase”
Talanta, 2016, 160, 586-591

DOI: 10.1016/j.talanta.2016.07.062   |   PDF (1.0 MB)


S. Sindhwani*, A.M. Syed*, S. Wilhelm, D.R. Glancy, Y.Y. Chen, M. Dobosz, W.C.W. Chan, “Three-dimensional optical mapping of nanoparticle distribution in intact tissues”,
ACS Nano, 2016, 10, 5468-5478

Highlighted on journal cover page (ACS Nano; Volume: 10; Issue: 5; May 24, 2016)
* authors contributed equally

DOI: 10.1021/acsnano.6b01879   |   PDF (9.4 MB)


S. Wilhelm, A.J. Tavares, Q. Dai, S. Ohta, J. Audet, H.F. Dvorak, W.C.W. Chan, “Analysis of nanoparticle delivery to tumours”
Nature Reviews Materials, 2016, 1, 16014

Highlighted on journal cover page (Nature Reviews Materials; Volume: 1; Issue: 5; May 5, 2016)

DOI: 10.1038/natrevmats.2016.14   |   PDF (1.0 MB)


E. Scheucher, S. Wilhelm, O.S. Wolfbeis, T. Hirsch, T. Mayr, “Composite particles with magnetic properties, near-infrared excitation, and far-red emission for luminescence-based oxygen sensing”
Microsystems & Nanoengineering, 2015, 1, 15026

DOI: 10.1038/micronano.2015.26   |   PDF (0.4 MB)


S. Wilhelm, M. Kaiser, C. Würth, J. Heiland, C. Carrillo-Carrion, V. Muhr, W.J. Parak, O.S. Wolfbeis, U. Resch-Genger, T. Hirsch, “Water dispersible upconverting nanoparticles: effects of surface modification on their luminescence and colloidal stability”
Nanoscale, 2015, 7, 1403-1410

DOI: 10.1039/C4NR05954A   |   PDF (2.5 MB)


V. Muhr, S. Wilhelm, T. Hirsch, O.S. Wolfbeis, “Upconversion nanoparticles: from hydrophobic to hydrophilic surfaces”
Accounts of Chemical Research, 2014, 47, 3481-3493

DOI: 10.1021/ar500253g   |   PDF (10.1 MB)


M. Del Barrio, S. De Marcos, V. Cebolla, J. Heiland, S. Wilhelm, T. Hirsch, J. Galbán, “Enzyme-induced modulation of the emission of upconverting nanoparticles: towards a new sensing scheme for glucose”
Biosensors and Bioelectronics, 2014, 59, 14-20

DOI: 10.1016/j.bios.2014.02.076   |   PDF (1.0 MB)


S. Wilhelm, M. Del Barrio, J. Heiland, S.F. Himmelstoß, J. Galbán, O.S. Wolfbeis, T. Hirsch, “Spectrally matched upconverting luminescent nanoparticles for monitoring enzymatic reactions”
ACS Applied Materials & Interfaces, 2014, 6, 15427-15433

DOI: 10.1021/am5038643   |   PDF (1.9 MB)


S. Wilhelm, T. Hirsch, W.M. Patterson, E. Scheucher, T. Mayr, O.S. Wolfbeis, “Multicolor upconversion nanoparticles for protein conjugation”
Theranostics, 2013, 3, 239-248

DOI: 10.7150/thno.5113   |   PDF (2.3 MB)


C. Fenzl, S. Wilhelm, T. Hirsch, O.S. Wolfbeis, “Optical sensing of the ionic strength using photonic crystals in a hydrogel matrix”
ACS Applied Materials & Interfaces, 2013, 5, 173-178

DOI: 10.1021/am302355g   |   PDF (3.3 MB)


S. Wilhelm, T. Hirsch. E. Scheucher, T. Mayr, O.S. Wolfbeis, ”Magnetic nanosensor particles with luminescence upconversion capability“
Angewandte Chemie International Edition, 2011, 50, 37, A59-64

DOI: 10.1002/anie.201105813   |   PDF (0.6 MB)


S. Wilhelm, O.S. Wolfbeis, “Irreversible sensing of oxygen ingress”
Sensors and Actuators B: Chemical, 2011, 153, 199-204

DOI: 10.1016/j.snb.2010.10.037   |   PDF (0.5 MB)


S. Wilhelm, O.S. Wolfbeis, “Opto-chemical micro-capillary clocks”
Microchimica Acta, 2010, 171, 211-216

DOI: 10.1007/s00604-010-0456-4   |   PDF (0.2 MB)