Research

The Biomedical Nano-Engineering (BNE) Laboratory led by Dr. Stefan Wilhelm has a broad interest in engineering biomaterials and colloidal nanomaterials for the diagnosis and treatment of diseases, including cancer. Our areas of expertise include the design and synthesis of organic and inorganic nanomaterials with defined physicochemical properties (e.g., size, shape, surface chemistry, and optical/magnetic features).

Our group studies interactions between nanomaterials and biological systems from a whole organ/tissue perspective down to the cellular and bio-molecular level. This research will provide a foundation for the rational engineering of nanomaterials and nanomedicines with the ultimate goal of designing diagnostic and therapeutic nanomedicines that are safer and more effective.

Research Areas

Nanotechnology-biology (“nano-bio”) interactions
Using novel bioanalytical tools, we study nanoscale and nano-bio interactions at the single-particle and single-cell levels.

Nanoparticle surface engineering and nanotoxicity of biomaterials
Using innovative nanoparticle surface engineering strategies, we study nanoparticle pharmacokinetics, biodistribution, and adverse effects.

Cancer nanomedicine
Understanding nanoparticle interactions with the tumor microenvironment for safer and more effective cancer drug delivery.

Immunoengineering and drug delivery
Targeted delivery of peptides, polysaccharides, and nucleic acids to immune cells for immunotherapy and vaccine applications.

Super-resolution imaging
Expansion microscopy of cells, tissues, and organs to elucidate nanoparticle transport and fate.

Research Environment

Our laboratory is located in the state-of-the-art biomedical research facility Gallogly Hall (opened in Fall 2019). We are a member of the NCI-designated Stephenson Cancer Center with access to unique research facilities and collaborators at the University of Oklahoma Health Sciences Center campus.